For greater than a century, scientists have observed water has a wide range of uncommon properties that don’t match throughout the basic mannequin of it being only a stable, liquid or gasoline.
Gerald Pollack constructed upon these observations, and finally decided that when a negatively charged floor is current, if an applicable power supply can also be current (notably infrared — which is in all places), the water will assemble itself into layers of offset hexagonal sheets with the system H3O2 that behave like a liquid crystal.
Word: Along with mild, sound may also generate H3O2.
In my eyes, liquid crystalline water is a critically underneath appreciated space of science because it supplies a mechanism to elucidate most of the unexplained mysteries of the physique (e.g., how accomplish that many fluids stream inside it regardless of there being no identified pump to maneuver them) and a technique to put phrases into a lot of what we regularly observe throughout the physique.
What Is Liquid Crystalline Water?
Liquid crystalline water has a big diploma of solidity, and can expel most issues from getting into it (e.g., polystyrene microspheres), together with the displaced hydrogen atoms (as it’s H1.5O not H2O). These displaced positively charged H atoms (henceforth known as protons), in flip assemble instantly exterior this lattice, thereby making a pH and cost gradient which could be measured.
In lots of instances, these H3O2 lattices could be monumental — in favorable situations, Pollack and others have measured ones starting from 0.1 millimeters to 0.5 millimeters (100,000 to 500,000 nanometers or nm) in measurement. Cells rely upon this water, in order that they include a lot of surfaces from which the water can kind.
For instance, 20% of the cell is occupied by its cytoskeleton (a protein lattice which maintains its construction), and evaluation of high-voltage electron micrographs have proven that throughout the cytoskeleton, over half of the water current is inside 5 nm of a floor it may doubtlessly kind H3O2 on (for reference a single H2O molecule is 0.27 nm in measurement).
Because the floor websites that water can construction on are so intently packed collectively in cells, it’s comprehensible why liquid crystalline water (additionally generally known as EZ water) could be a lot extra obvious to people observing residing cells underneath a microscope (which actually is the place a lot of the early analysis on H3O2 originated from). This in flip raises one other query: why are cells designed to create a lot liquid crystalline water?
Word: An extended article describing the lengthy historical past of analysis into liquid crystalline water (H3O2) and its bodily properties could be learn right here.
Mysteries of the Cell
Within the earlier article, I mentioned a standard concern I observe inside science. When an incorrect mannequin is utilized to elucidate a pure course of, discrepancies between the mannequin’s predictions and actuality will inevitably seem.
One would count on that when this occurs, it will encourage these espousing the misguided mannequin to re-examine their mannequin, however as a substitute, since a lot has been invested into that mannequin, they as a substitute will denounce any challenges to it, and give you innumerable inventive methods to elucidate away every failure of the present mannequin.
Contemplate, for instance, the preliminary guarantees of the vaccines (should you get two doses, you had been informed that you’d be utterly immune, transmission would cease, and COVID-19 would quickly fade into reminiscence). Because the scientific trials for the vaccines had been fraudulent, not one of the vaccines’ guarantees materialized, and the COVID scenario as a substitute turned worse.
Nonetheless, as a substitute of healthcare authorities (and the medical group) admitting their mistake and switching to a distinct strategy for managing COVID-19, they doubled down on the vaccine mandates and moved the purpose posts again and again with reference to what mass-vaccination (and boosting) was truly supposed to perform.
Likewise, for mobile biology, our information of the cell is surprisingly primitive and the present fashions usually fail to elucidate what happens throughout the mobile setting. Nonetheless, because the different fashions usually are not usually accepted by the scientific group, we now have been compelled to repeatedly patch the present fashions in order that they’ll considerably account for the innumerable mysteries of life.
At this level, I imagine one of many key causes of this example is scientific analysis turning into distorted to prioritize specializing in discoveries that trade can revenue from.
For instance, immunology has a slender deal with the features of the immune system which could be focused by vaccination or proprietary medication, which in flip has left many different parts of the immune response uncared for (the immune system is often known as one of many least understood techniques within the physique).
Equally, since pharmaceutical medication usually work by affecting receptors and channels in cells, mobile biology has adopted a narrow-minded deal with simply these features of a cell.
In flip, the liquid crystalline section of water supplies a wide range of explanations for most of the organic phenomena that the present fashions merely don’t adequately deal with. On this article, I’ll focus upon just a few of them.
Word: A lot of what’s mentioned on this article is roofed in additional element inside these three books (equally, nearly all of the references for this text are sourced from these books, so I cannot repetitively cite them all through the article). Should you want to additional research the topic your self, I’d advocate studying these books (all authored by Gerald H. Pollack) on this order:
- The Fourth Section of Water: Past Stable, Liquid, and Vapor (2013)
- Cells, Gels and the Engines of Life: A New, Unifying Strategy to Cell Perform (2001)
- Section Transitions in Cell Biology (2008) — that is essentially the most technical of the three
Mobile Integrity
One of many main puzzles of biology is the immense sturdiness that cells have. Should you think about the basic mannequin — cells being baggage of liquid contained inside a fluid mosaic membrane, it needs to be easy for exterior forces to “pop” cells and have all of their contents spill out. But normally, cells preserve their integrity regardless of vital stressors.
Cells can survive traumas, together with being guillotined in half, drawn and quartered (so particular parts could be remoted and labored with — corresponding to when performing in vitro fertilization), or shot stuffed with holes with electrical bullets, every of which one would count on could be ample to “pop” them. Nonetheless, in every occasion, mobile integrity of the remaining element persists.
Equally, if the membrane from a cell is eliminated, its inner contents stay in place moderately than quickly dispersing. It has additionally been identified for over 50 years that if muscle fibers lose their membranes, their practical capability (making a contractile power) stays intact.
Three clues assist to elucidate these phenomena. The primary is that — as Pollack has proven — water droplets have a exceptional quantity of integrity, and like cells, will preserve their integrity (and subsequently fuse again collectively) if a micro-blade is used to guillotine them in half. The second is that Pollack has additionally proven water droplets include a big diploma of liquid crystalline water which probably is what confers their integrity.
The third is that the water molecules in cells predominantly exist inside gels, that are composed of that very same liquid crystalline water. Put in a different way, which means that a cell’s stability is essentially a property of its water holding it collectively moderately than the exterior construction which encapsulates it.
One other essential side of mobile structure ought to now be thought-about. Because the situations for liquid crystalline water formation are current all through the cell (negatively charged hydrophilic surfaces and ambient infrared power), the cells ought to quickly be filling themselves with liquid crystalline water layers tons of of micrometers in thickness.
But, all through the cells, the surfaces are sometimes solely fractions of a micrometer aside. Which means that the construction of the cell relies upon upon the continuous formation of liquid crystalline water, however concurrently constrains that crystalline construction from rising to its full measurement.
Tensegrity
Classically in structure, buildings are created by having sturdy skeletons upon which the remainder of the construction rests. For instance, within the previous days, we regularly used stone pillars; these days, skyscrapers require metal superstructures to fulfill the wants of those buildings:
This mannequin usually doesn’t work inside residing organisms, as a result of life, not like these buildings, requires speedy motion, and residing organisms merely can’t produce stable buildings with the identical power as metal beams. Nonetheless, another and extra advanced architectural mannequin has been developed which is regularly utilized by those that embrace complexity inside their fashions.
Tensegrity (quick for tensional integrity), was a mannequin first put ahead by Buckminster Fuller. It posits that if a collection of non-compressible buildings are linked collectively by a lattice of elastic connections (which may retailer stress when stretched), a a lot stronger construction is created.
It’s because any power the construction receives shall be equally distributed by means of every of these elastic connections moderately than concentrating on a single element (e.g., the stone pillar), and thus, a lot much less prone to exceed the breaking level of any single structural element.
Fuller’s work subsequently impressed quite a few buildings to be constructed on the rules of tensegrity. This can be a basic image of him holding a tensegrity sphere he made:
Biotensegrity encapsulates the belief that this identical system additionally happens all through nature. For the human physique, at every degree of group, a linked tensile matrix is current that confers its stability.
One French hand surgeon, Jean-Claude Guimberteau, has likewise carried out a exceptional job of demonstrating the presence of linked tensile buildings on the degree of fascia (a connective tissue current all through the physique many handbook therapists work with), by means of small (magnified) cameras positioned within the physique throughout minimally invasive surgical procedures:
Word: On the magnification scale used right here and in his different movies, liquid crystalline water could be immediately noticed coating these buildings. Additionally word its lubricating high quality that enables the buildings to slip previous one another. Lack of this lubrication seems to create a wide range of points throughout the physique.
Because the years go by, there seems to be a better consensus throughout the holistic medical subject that biotensegrity is a sound mannequin for understanding the physique, and that linked networks of stress are current from the most important to the smallest ranges of the physique (e.g., the cytoskeleton is the elastic connecting unit inside every cell). Nonetheless, whereas this concept is regularly mentioned, there are nonetheless two main unaddressed points with it, which I imagine liquid crystalline water can clarify.
The primary is that in Guimberteau’s work, he had noticed that tiny vacuoles (enclosed compartments full of water) all through the physique kind the fundamental incompressible unit that a lot of the physique’s tensegrity relies upon upon.
The second is that at a good larger magnification inside cells, whereas a cytoskeleton is current that’s underneath stress, there’s nothing that may be seen which creates that stress (and it’s extremely debatable if the cell’s connections to the extracellular matrix suffice to create that stress). This issues as a result of the structural power of a tensegrity system solely emerges when a construction’s parts are underneath stress.
Within the case of the previous, I imagine that the microvacuoles are full of liquid crystalline water (which can’t be compressed). Within the case of water droplets, Pollack concluded that the mutual repulsion between positively charged protons (pushed to the middle of the droplet by sheets of H3O2) creates an outwards power resisted by the liquid crystalline boundary of the droplet.
The steadiness between these two forces leads to the droplet assuming a spherical kind, and I imagine the identical mechanism is at work within the microvacuoles all through the human physique.
Within the case of the latter, you will need to keep in mind how a lot enlargement is produced by proteins that create gels (many gels are over 99.9% water). Pollack, in flip, has proven that the liquid crystalline water that’s consistently attempting to kind throughout the cell is unable to achieve its full measurement as a result of proteins resisting the stretch that must happen had been the liquid crystalline gel to develop to its full measurement.
This occurs each on the degree of the cell (because the cytoskeleton stretches because the cell expands to its most measurement, till it can’t permit additional enlargement to happen) and inside proteins all through the cell.
On the protein degree, the physique usually depends upon chemical bonds to be made between proteins to constrain the utmost enlargement that may happen in response to a gel forming. Moreover, proteins can alternate between a folded and an unfolded conformation (e.g., a helix vs. a coil), one thing usually decided by the strain utilized to the protein (such because the expansive strain of liquid crystalline water inside a gel).
There are a selection of significance penalties of this conformation change which shall be mentioned later on this article (e.g., for the physiology of muscle tissue). Moreover, many different parts of the physique additionally seem to depend on liquid crystalline water:
“Finding out collagen, Melacini et al. famous the significance of water in stabilizing its triple helix crystalline construction. They discovered that water throughout the collagen helix kinds a “semi-clathrate-like construction that surrounds and interconnects triple helices within the crystal lattice.”
Water throughout the matrix of bone is likewise extremely structured, a structuring that has been discovered related not solely with natural macromolecules corresponding to collagen and proteoglycans, however with the mineral surfaces as effectively. Water, actually, appears to play a foundational position in orienting mineral nanoparticles into parallel preparations throughout the bone matrix, offering this orientation even within the absence of natural molecules.”
On a regular basis Gel Expansions
Many applied sciences we’re conversant in (e.g., diapers) depend on hydrogels which may develop right into a semisolid construction which retain water. Equally, we are able to immediately observe that many bigger processes throughout the physique are additionally dependent upon water’s tendency to assemble into the bigger liquid crystalline buildings.
As a result of the conventional structure of protein’s cross-linking habits limits how a lot gels can develop (because the proteins which would wish to separate to accommodate the rising gel are prevented from doing so by cross hyperlinks between them), when tissue or protein is broken, this limitation could be partially eliminated. Consequently, it may be seen on a microscopic scale that human tissue will swell and develop when it’s broken.
Likewise, Pollack has argued that that is most definitely what occurs if you expertise a musculoskeletal trauma. In Pollack’s proposed mannequin, the preliminary gel formation additional expands the present tear, and this progressive enlargement of liquid crystalline water finally results in seen swelling.
On a bigger scale, one of many main engineering challenges for the physique is having weight-bearing joints just like the knees be capable to preserve their vary of movement with out turning into broken by the continuous friction they expertise each day.
A exceptional attribute about liquid crystalline water is that, supplied the floor from which it kinds stays intact, liquid crystalline water could be destroyed after which reform, together with its virtually frictionless floor, again and again.
Due to this, the liquid crystalline water finally ends up being the element which absorbs the stress skilled by wholesome joints, and supplied the joint is wholesome, this water can immediately regenerate from that stress. At the side of this regenerating layer of negatively charged liquid crystalline water, on the very heart of the joint, there’s a pocket of positively charged protons which repel from one another and create an expansive strain (like what’s seen in a water droplet).
Because the joint capsule seals this area, these protons are unable to flee and thus successfully operate like repelling magnets (e.g., think about a maglev practice) that resist the load of the physique and preserve the central area throughout the joint.
One of many issues I think about essentially the most compelling about Pollack’s mannequin for the joints is the precise high quality of synovial fluid contained in the knee joint. Whenever you view it on a digital camera throughout an arthroscopic surgical procedure, diffusion inside it’s visibly slowed, whereas should you immediately extract it (e.g., throughout a knee aspiration), you may inform that it has a a lot thicker and gelatinous high quality, one thing I’ve discovered to affiliate with the presence of liquid crystalline water.
Pollack likewise argues that his mannequin suggests EZ (liquid crystalline) water’s habits resembles that of a gelatinous egg white which is semisolid when left alone, but capable of stream in response to an imposed shear power.
Mobile Gradients
Word: A “gradient” describes a distinction within the focus of issues in two completely different areas. This might embody electrical prices (i.e. batteries depend on gradients), electrolytes, or temperatures — and lots of gradients present an simply harvestable supply of power.
The prevailing paradigm of physics asserts the next:
- The pure state of issues is to be disordered and evenly blended.
- Anytime you make one thing change into extra ordered (e.g., forming a crystal or making a gradient between two areas), power have to be expended to create that ordering.
- When an ordered construction turns into disordered, power is launched within the course of which may generally be harvested (e.g., combusting wooden in a wooden range to warmth our houses).
- Anytime power is launched from one thing, should you try to seize and retailer that power, some power will all the time be misplaced.
These legal guidelines, in flip, are used to refute the likelihood that any kind of “free-energy” system can exist, such because the exclusion zone (EZ) water system Pollack has proposed the place quite a few harvestable gradients are created. Sadly for the present paradigm, biology usually seems to violate these legal guidelines, as it’s frequently shifting in the direction of a extra ordered state moderately than the disordered state the present paradigm predicts.
The present decision for this paradox (which gained a Nobel prize) is that residing organisms operate as “dissipative buildings,” which change the order in massive quantities of ordered parts they accumulate from their setting in return for imparting order to their very own disordered contents.
Though to some extent this enables the present paradigm to maintain itself, I don’t imagine it’s completely correct as water, by means of its liquid crystalline construction, has the flexibility to retailer radiant power that passes by means of it and convert that power to order the physique can then make the most of.
The Sodium Potassium Gradient
One of many issues residing cells are well-known for doing is concentrating potassium inside themselves and reciprocally expelling sodium. Because the focus inside and outdoors cells differs, a gradient exists, which, by the present legal guidelines of physics ought to attempt to equalize itself and quickly disappear.
Since this doesn’t occur, the present mannequin has argued that the mobile membrane prevents the passage of most however not all sodium and potassium (thereby inhibiting the gradient from equalizing itself) and that sodium potassium pumps on the mobile membrane exist which continuous swap sodium contained in the cell for potassium exterior the cell.
As a result of this change is so very important to sustaining the well being of the cell, a big focus in mobile biology is positioned on the significance of the sodium potassium change pump. Sadly, there are three basic issues with this mannequin (the proof of every of those and extra is offered by Gilbert Ling right here):
- The maths doesn’t add up — the present sodium potassium pumps merely don’t have the capability to counteract the pure undoing of the sodium and potassium gradients. For instance, in muscle cells, sustaining the sodium potassium gradient with pumps requires between 4 to 30 occasions the whole obtainable power within the cell.
- Cells are capable of preserve a gradient with a wide range of different undesirable parts they expel (e.g., micro organism expelling antibiotics) and to elucidate these phenomena, an increasing number of pumps are recognized to attempt to help the mannequin. This can be a drawback as a result of it’s unlikely that cells have the capability to concurrently maintain so many various pumps.
- Ling took frog muscle cells whose setting was altered in order that they had been utterly starved of power (which is required to function the sodium potassium pump). Regardless of this, the gradient was maintained.
This then begs the query of what could possibly be creating this gradient? Ling made the next observations:
- The gradient was maintained if the cell membrane (the place these pumps reside) was eliminated.
- Producing a membrane with sodium potassium pumps that didn’t include a cytoplasm (the within of a cell) resulted within the gradient quickly disappearing from with the membrane.
This means that the gradient is a property of the cell cytoplasm moderately than the mobile membrane. Curiously, the similar property has been present in synthetic gels, which just like the cytoplasm, additionally generate massive quantities of liquid crystalline water:
“We present that the gel barrier is ready to preserve a secure separation of ionic options of various ionic strengths and chemical compositions with none pumping exercise. For the Na+ /Ok+ focus gradient sustained throughout the barrier, a damaging electrical potential develops throughout the Ok+ -rich aspect. The scenario is harking back to that within the cell.
Moreover, additionally the advective stream of water molecules throughout the gel barrier is restricted, regardless of the gel’s massive pores and the osmotic or hydrostatic strain gradients throughout it.”
This focus phenomenon has additionally been noticed by different authors:
“Proof for such accumulative condensation was produced virtually a century in the past when Bungenberg de Jong in 1932 confirmed that even dilute options of polymers, when shaken, coalesced into droplets-then known as coascervates-in which the natural matter turned extremely concentrated. The polymer focus in such droplets may exceed the focus within the surrounding bathtub by as a lot as 10,000 occasions.
When positioned in sure dyes, the droplets turned progressively extra coloured, the depth usually many occasions exceeding that of the encircling resolution. Thus, gel droplets had the capability to pay attention sure solutes, because the cell concentrates potassium.”
Since gels independently reveal most of the inexplicable traits of cells, it’s thus affordable to conclude they may share a mechanism for producing the sodium potassium gradient noticed all through biology.
Obstacles
One main problem for all cells is conserving undesirable issues out. Classically, we view the method of pathogenic substances getting into cells as being a product of their interplay with matching receptors on the cells (a world view which I imagine is emphasised by medical science as a result of medication could be developed to disrupt this course of). I, in flip, imagine that this exclusion course of by the cell is closely influenced by present prices, zeta potential and liquid crystalline water.
As a result of liquid crystalline water can for essentially the most half solely kind on negatively charged surfaces (the identical manner that water molecules every expel half a hydrogen atom and thereby maintain a internet damaging cost because of the misplaced hydrogens), virtually each floor within the physique (and lots of different pure techniques) is coated with a damaging cost.
Since colloidal stability (which governs the habits of most fluid techniques) largely relies upon upon the mutual repulsion created by similar prices, most pure colloidal techniques make the most of damaging prices to stay dispersed and solely clump collectively if extreme optimistic prices are current (likewise most strategies of restoring zeta potential function on this precept).
Pathogenic organisms usually impart optimistic prices to their setting (corresponding to by means of micro organism decarboxylating the damaging prices of amino acids inside proteins). This causes proteins and cells contained in the physique to start clumping collectively (the malaria parasite is especially good at doing this), which each prevents the immune system from having access to the microbes and will increase the microbe’s capability to achieve entry to the cells.
One of many notably attention-grabbing observations made by the unique proponent of physiologic zeta potential was that bacterial and viral infections (I imagine this was essentially the most studied with influenza) would create a constant degradation of the physiologic zeta potential. This supplies an evidence for why viruses like influenza could be a lot extra harmful for the aged.
Somebody with a wholesome zeta potential can tolerate a minor impairment of their colloidal stability (they may simply really feel a bit unwell), however for somebody who already has an impaired zeta potential (which is a quite common consequence of getting older), that discount could be ample to go a important threshold the place extreme sickness onsets.
One of many earliest distinguishing traits of COVID-19 to me was that many sufferers developed scientific indicators suggesting extreme zeta potential disruption, one thing I had not seen with another respiratory virus. A key cause I used to be involved in regards to the spike protein lengthy earlier than the vaccines entered the market, was as a result of I had recognized it because the probably wrongdoer for this zeta potential disruption.
This was as a result of it being a novel element of the SARS-CoV-2 virus (it differed from that of SARS-CoV-1) that was current on the floor of the virus and which had an unusually excessive optimistic cost density. It has since been proven that the spike protein immediately induces clumping of pink blood cells, probably as a result of its cost distribution having the potential to create a big disruption of physiologic zeta potential.
One of many attention-grabbing feedback I’ve repeatedly seen acknowledged by each people who’ve taken protocols to enhance their physique’s manufacturing of liquid crystalline water and people who’ve carried out the identical for enhancing their zeta potential, is that they not often get sick.
This might doubtlessly imply both that the signs of infections are far more minor if these physiologic parameters are already in good well being (e.g., because you don’t go a important zeta potential threshold), or as a result of they immediately forestall cells from turning into contaminated by pathogens.
As many elements which positively have an effect on one of many parameters usually have an effect on the opposite (e.g., earthing improves zeta potential and promotes the expansion of liquid crystalline water within the physique), it’s a bit exhausting to say which impact finally predominates, and an important deal of my analysis on this matter was primarily based on attempting to reply that query.
Word: The strategies of restoring zeta potential and growing liquid crystalline water throughout the physique are mentioned additional right here.
On this article, we evaluation a number of the proof supporting that barrier speculation. The earliest I got here throughout was from the work of Viktor Schauberger (1885-1958), who believed it was critically essential for water to journey in a vortexing sample, one thing as mentioned within the earlier a part of this collection, has been proven to extend the presence of liquid crystalline water.
One of many many discoveries made by using vortexing techniques primarily based on his design for water provides was that it decreased the expansion of micro organism throughout the water system (e.g., on the within of pipes).
Different analysis has immediately discovered that the presence of liquid crystalline water prevents the expansion and invasion of micro organism, corresponding to this research:
“In a check performed with E. coli, cells progressively penetrated EZ [liquid crystalline water] over 2 days. Moreover, EZ-bearing Nafion had 80% much less biomass accumulation of E. coli over 2 days in comparison with an EZ-less, hydrophilic, clean aluminum oxide floor. This means that EZ might symbolize the primary line of protection, spatially and temporally, towards micro organism approaching sure hydrophilic surfaces.
These findings may have essential implications in growing biofouling-resistant materials surfaces for functions delicate to bacterial attachment and biofilm formation.”
And this research:
“Silk sericin is a globular protein whose resistance towards fouling is essential for functions in biomaterials and water-purification membranes. Right here it’s proven how sericin generates a water-exclusion [liquid crystalline] zone which will facilitate antifouling habits. Negatively charged microspheres had been used to imitate the floor cost and hydrophobic domains in micro organism.
Immersed in water, sericin shaped a 100-µm-sized exclusion zone (for micron-size foulants), together with a proton gradient with a lower of >2 pH-units. Thus, when involved with sericin, water molecules close to the floor restructure to kind a bodily exclusionary barrier that may forestall biofouling.
The decreased pH turns the aqueous medium unviable for neutrophilic micro organism. Subsequently, resistance to biofouling appears explainable, amongst different elements, on the idea of water-exclusionary phenomena.”
Many tissues rely upon the presence of liquid crystalline water lining them, and that is probably at the least partly, because of the protecting barrier they create. Inexperienced and Otori in 1970, for instance, discovered exclusion zones roughly 350 μm deep extending from the cornea, and likewise from contact lenses (it’s essential to guard the attention from harm, and liquid crystalline water capabilities as a clear, well-lubricated barrier, qualities each important for the eyes).
Pollack, roughly 15 years in the past, additionally discovered similar outcomes (the presence of liquid crystalline water) subsequent to polyNIPAM, the gel used to manufacture contact lenses.
One of the essential tissues within the physique for offering a protecting (however well-lubricated layer) is on the endothelial lining of the blood vessels. There, massive quantities of blood creating vital shear forces consistently go over the blood vessels. So far, Malcom Kendrick has famous that the areas of circulation which expertise the best shear forces are the most definitely to develop the power harm which finally results in coronary heart illness.
The protecting coating of the endothelium, the glycocalyx, is structured (as a result of its excessive sulfate content material) to create massive quantities of gel (liquid crystalline water) round it and thus defend the endothelium. Moreover, a skinny layer that blood cells can’t enter is understood to immediately line the partitions of even the smallest blood vessels.
Equally, researchers in 2000 noticed a 0.4-0.5μm thick gelled layer of water lining the endothelium of wholesome capillaries (the smallest blood vessels within the physique), and this lining excludes a wide range of completely different substances from reaching the endothelium.
Formally, the vaccine spike protein can’t have an effect on the endothelium as a result of it lacks a practical ACE2 binding area (whereas the COVID-19 virus has a practical one by means of which it then enters the cell).
Though that is the case, there are many different methods that the spike protein can nonetheless connect to the endothelium (e.g., the spike protein can nonetheless connect to the receptor, it immediately binds heparin within the glyocalyx, and whether it is produced from contained in the endothelium by the vaccine, it has successfully entered the endothelium).
Since autopsies of people suspected to have died as a result of vaccination have revealed profound harm to the endothelial layer, this supplies sturdy proof that the spike protein in a technique or one other has the flexibility to penetrate the usually protecting barrier there.
Many have suspected that that is partly because of the extremely optimistic cost that the spike protein (and the generally positively charged parts of the lipid nanoparticles) carries, as these optimistic prices can penetrate the liquid crystalline water barrier defending cells just like the endothelium.
I imagine it could even be because of the spike protein’s disruption of zeta potential, as different states related to elevated blood viscosity (e.g., uncontrolled diabetes) are identified to harm the endothelium and speed up the development to heart problems.
Section Transitions
Though liquid crystalline water is important for all times, an excessive amount of of it can be problematic. For instance, if your complete cell was lined with gel-state water, it will not be doable for a lot of issues that wanted to enter the cell to enter.
To unravel this drawback, areas of optimistic cost exist within the membrane (e.g., Pollack argues that it is a key cause for the position of metallic ions throughout the cell membrane), which forestall liquid crystalline water from forming over the world and thus create an open passage for water to journey by means of.
Word: Though we’re taught to think about the cell as a fluid mosaic of phospholipids with proteins right here and there, roughly 50% of the cell membrane is often composed of proteins (and it might probably generally be much more).
Typically, nonetheless, the physique depends upon with the ability to remodel water between its gel (liquid crystalline) state and a sol (bulk water containing colloidal suspensions) state as wanted. Nonetheless, whereas recognition of the elemental significance of section adjustments in mobile biology has progressively elevated during the last 70 years, nearly all of the scientific subject continues to be wedded to the fluid mosaic speculation, which believes that the mobile membrane is all the time a liquid.
Briefly, gels (each pure and artificial ones) usually have a temperature (its transition level) the place the gel will endure a speedy transition from one state to the opposite (defined additional right here). So far as I do know, in all instances, the warmer temperature will correspond to the sol state (H2O water with suspended colloids) and the colder one will correspond to the gel state (H3O2). Moreover, elevated strain may also promote the gel state:
“Organic exercise virtually universally requires that membranes be of their fluid state; in lots of instances, simply above the transition level.”
Gels all through the physique, in flip, are designed to have a section transition level close to the conventional temperature of the physique. This may occasionally clarify why most mammals and birds preserve their temperature between 35°– 42°C (95°– 107.6°F; the conventional temperature for people is 37°C or 98.6°F), an in any other case curious truth given how a lot their our bodies and environments differ (e.g., a tiny chicken within the desert vs. a blue whale).
Moreover, this temperature extends past warm-blooded animals. A tuna fish, when lively, maintains the temperature of its physique at 30°C or 86°F (the ocean is far colder) whereas many reptiles preserve their physique temperature close to 40°C or 104°F (by doing issues like searching for out the solar). Many bugs additionally can’t fly till they’ve warmed as much as an analogous vary of temperature (e.g., 38°C or 100.4°F for bumblebees).
Equally, the section transition level is closely influenced by the supplies that the gel builds from (e.g., parts of the cell membrane). Chilly-blooded animals in flip have been noticed to vary the composition of their cell membranes in response to their setting.
In a single experiment, Calotes versicolor (the widespread backyard lizard), had been acclimatized to 16°, 26°, and 36°C (60.8°, 78.8°, and 96.8°F) for a interval of thirty days. The lizards exhibited dramatic adjustments within the focus of main phospholipids (parts of the cell membrane) corresponding to phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, cardiolipin, and sphingomyelin.
Temperature acclimatization has additionally been noticed to fluctuate the lipid composition of carp muscle microsomes together with carp blood cells, and seasonal variation has been noticed within the lipid composition of brains of rainbow trout.
As soon as the gel is held close to its transition temperature, it’s then relative straightforward to vary precisely the place that transition temperature is so water could be saved within the applicable section for the present physiologic wants. That is primarily carried out throughout the physique by altering the electrolyte composition of the world, as sturdy cations (positively charged ions) destroy gels, whereas sturdy anions (negatively charged ions) reinforce them.
So far as I can inform, the consequences of those ions correlate to the excessive valence (cost) anions (-) that almost all successfully help physiologic zeta potential and people excessive valence cations (+) which most successfully destroy it.
The first cation factor which the physique makes use of to shift the transition temperature with a view to destroy gels is calcium (Ca). For example the impact of calcium graphically (word how a sudden important threshold of Ca focus is reached):
These outcomes additionally confirmed how the upper valence cations, Ca2+, trigger smaller gels to kind relative to low valence cations Na(1)+.
As soon as you place all of this collectively, you successfully get a scenario like this throughout the cells which permits small secretions of calcium there to shift its water from a fluid to a gel state.
Conversely, if the physique can disperse the gels, it additionally wants a technique to recreate them. The first sturdy (excessive valence) anion it makes use of to construct them are the phosphates in adenosine triphosphate (ATP).
Once we think about this different operate of ATP, we should always think about a number of the concepts first proposed by Ling (see 8.4 on web page 178). They recommend that a lot of the power obtained from ATP arises not from the power inside its bonds being damaged, however moderately from it inducing water to kind a liquid crystalline construction. In essence, a lot of the power generated from ATP finally arises from the radiant power which triggers these polymerizations (gels).
Section transitions are quite common in mobile biology, and whereas the sector doesn’t place a heavy emphasis on their significance, Pollack’s central argument in his first two books is that section transitions are needed to elucidate many capabilities of the cell.
Word: Once I later mentioned my articles with Pollack, he knowledgeable me that the principle oversight together with his earlier analysis was that that they didn’t but know that the gels had been negatively charged, which in flip explains a wide range of the consequences they create (e.g., {the electrical} impulse of nerves).
Increasing Gels
One of many main makes use of for gels throughout the physique is from them to quickly develop and create results from that enlargement. For instance, cells regularly excrete small spheres (generally known as vesicles) containing essential parts, which upon exiting the cell quickly develop. Remoted mucin-producing vessels for instance endure a 600 fold enlargement in 40 milliseconds.
Previous to exiting the cell, the inner parts of the vesicle are cross linked collectively by Ca2+ (keep in mind, larger valence cations, by means of crosslinking gel proteins, will restrict gel formation whereas monovalent cations like sodium as a substitute are likely to develop them).
As soon as secreted from the cell, Ca2+ is eliminated and the gel quickly hydrates within the Na(1)+ resolution surrounding every cell. Conversely, gels is not going to quickly develop in distilled water, and it has been noticed that liquid crystalline water’s formation can also be diminished inside deionized water.
Word: Some vesicles make the most of native environmental elements to vary their section. For instance, histamine is a monovalent cation (cost of +1) at a impartial pH, however turns into a divalent cation (cost of +2) in an acidic pH. Researchers had been capable of present that histamine in an acidic setting (as a result of its excessive valence state), causes shrinking of mast cell granules, whereas histamine in a impartial setting permits their enlargement.
Muscle Physiology
Lots of the commonest issues for which sufferers search out physicians originate from the muscle tissue. Due to this, I’ve checked out a number of other ways to deal with these points. In flip, I’ve discovered fairly just a few that persistently work however I can’t clarify why as the present mannequin of muscle physiology can’t present an evidence.
One of many main issues with medication (and sometimes science) is what I time period the “mechanistic lure.” Briefly it implies that if there’s not a mechanism to elucidate why one thing works, then it’s assumed to be a hoax and thought to not truly work. I feel this compulsive want for a mannequin is sort of silly, particularly since most of the fashions we make the most of to elucidate why medication work, don’t truly make sense.
Equally, there are lots of instances of a beforehand accepted mannequin for a drug’s mechanism that was discarded and changed with one other, and I do know of many extra examples the place an unorthodox mannequin seems to supply a significantly better rationalization for the mechanism of a remedy.
Word: This additionally holds true for a lot of different non-drug therapies.
Sadly, it’s practically unattainable to have the FDA (or many conventionally skilled physicians) be open to contemplating a remedy for analysis except a biochemical mechanism for it’s proposed. I imagine it is a reflection of the actual fact pharmaceutical medication, as they’re designed to focus on sure enzymes within the physique, match into our inflexible mechanistic paradigm, whereas therapies with a broad spectrum of motion can’t be linked to a selected biochemical receptor nor as simply profited from.
Given all of this, I used to be overjoyed to find by means of Pollack that many features of the present mannequin for muscle physiology don’t make sense, and the anticipated outcomes of the mannequin don’t happen when rigorous experiments on muscle tissue are performed:
Nonetheless, another mannequin for muscle physiology additionally exists. As we think about it, we should always remember that muscle tissue are acknowledged to solely be able to contracting. Within the situations the place one thing within the physique wants to elongate, that is achieved by having a muscle in the appropriate place shorten, and as a result of its place, create a lengthening elsewhere by means of doing so (e.g., the triceps within the arm).
From Pollack’s work, I noticed that whereas muscle tissue can solely create power throughout a contraction, that is truly a results of the actual fact their parts can solely forcefully lengthen.
Pollack’s mannequin is predicated on the remark that relaxed muscle tissue include a considerable amount of structured water, whereas contracting muscle tissue primarily include water not in a semisolid gel state. Since it’s identified that muscle firing follows the nerve sign directing calcium (Ca2+) ions to enter the muscle, this implies a calcium induced section change might underlie the method.
Conversely, it is usually identified (from the experiment beforehand described within the gradient part) that whereas muscle cells which have been reduce open can retain their potassium to sodium gradient whereas in a salt resolution, the components that lack ATP are unable to.
This means that ATP is important for the liquid crystalline state of water to be current, because it excludes sodium ions from getting into the muscle cells. Equally, it is usually identified that with out ATP, muscle tissue will stay caught within the contracted kind and be unable to elongate, one thing that happens shortly after demise (termed “rigor mortis”).
Word: One of many compelling anecdotal tales I’ve heard over time is that when severely vaccine-injured youngsters die (e.g., these with lifelong debilitating autism) rigor mortis units in a lot sooner for them. Those that noticed this advised that these youngsters had a power power deficit, and their our bodies had been struggling to make sufficient ATP to get by. I feel that is very doable, nevertheless it is also indicative of poor zeta potential.
I think this may additionally be seen with different power debilitating sicknesses, however I’ve not interacted with the individuals who would have noticed if it did actually happen.
Pollack additionally noticed that muscle adjustments in response to environmental elements adopted a well-known important threshold being handed. This additionally appeared to recommend to Pollack {that a} section change was occurring throughout the muscle tissue.
So what’s Pollack’s mannequin? The muscle tissue fibers are designed to kind massive gels round them, and as liquid crystalline water inside them expands, it stretches the uncoiled proteins within the fibers into helixes (till protein cross hyperlinks forestall additional stretching). When the muscle must contract, calcium ions enter the muscle, eliminating the gels, and the proteins not being lengthened elastically snap again to their authentic uncoiled configuration.
To ensure that the gel to rebuild, ATP is required to interrupt the cross hyperlinks created by calcium and thereby set off a section shift that reconstructs the gel.
Thus, the power of a muscle is a product of the potential power created by liquid crystalline water’s storage of radiant power being launched. Or put in a different way, the power of muscle tissue truly lies of their capability to spontaneously lengthen and explains why many efficient muscular remedies I’ve come throughout work.
Massive mechanical shear causes the cytoskeleton matrix [another key structure that expands and contracts in response to phase changes] to fluidize, a phenomenon just like bodily rejuvenation in SGM’s [certain synthetic materials]. This fluidization is adopted by a sluggish scale- free restoration of mechanical properties, a phenomenon just like bodily getting older in SGMs.
Surprisingly in response to a transient stretch, the cytoskeleton fluidizes in a sample that’s common for various cell sorts. This discovering implicates mechanisms mediated not a lot by particular signaling pathways, as it’s normally assumed, however moderately – as we clarify beneath – by non-specific actions of bodily forces.
Many different buildings even have the flexibility for his or her inner gels to trigger enlargement and contraction, however not like skeletal muscle tissue, normally, this enlargement and contraction shouldn’t be as tightly constrained as what’s noticed throughout the closely cross-linked skeletal muscle tissue.
Easy muscle tissue, in addition to contractile rings, artificial actin gels (actin is without doubt one of the commonest contractile proteins within the physique), and different organelles with few covalent cross hyperlinks and semi-random buildings are different examples of locations the place the physique makes use of this precept to maintain life.
Lastly, it has additionally been noticed that altering the encircling concentrations of salinity round different fibers (e.g., collagen) could cause them to develop and contract to the purpose they’ll generate a power yielding contraction just like that of a muscle fiber.
Conclusion
There have been just a few central questions I’ve sought to deal with in my exploration of liquid crystalline water. On this collection, I sought a mechanism to elucidate the remark in quite a few conventional medical techniques that an inherent expansive power exists all through the physique which performs a key position in offering its vitality and that when this expansive power is compromised, a wide range of ailments set in.
I agree with this perception and have seen quite a few situations the place it turned doable to acknowledge the place that life sustaining enlargement had been changed with a decent compacted area, and likewise seen strategies that sought to revive that enlargement additionally restore a affected person’s vitality.
Conversely, I imagine the lack of mobility and sturdiness that accompanies getting older (and one of many largest issues to elder sufferers) is immediately associated to the lack of liquid crystalline water we usually expertise with age.
On this article, I’ve tried as an instance the structural results of liquid crystalline water throughout the physique, and it’s my hope that by means of doing so, I’ve supplied a mechanism to elucidate the place that expansive power originates from. Within the subsequent a part of this collection, I clarify how water’s liquid crystalline state creates a gradient that may be harvested for power and creates the circulation life relies upon upon.
Within the article after that, I did my finest to elucidate the intertwined relationship between liquid crystalline water and zeta potential, and within the last a part of this collection I mentioned the strategies I’ve come throughout which seem to revive both.
Every of those subjects is sort of advanced (e.g., this text was a synthesis of quite a few books and articles), however for my part nonetheless essential to dive into for unravelling the mysteries of life. In flip, it’s my honest hope the widespread awakening that has occurred in our society because of COVID-19 can rekindle curiosity to discover unconventional topics like this.
I thank every of you for the eye you gave in attempting to understanding this comparatively advanced matter which is close to and pricey to my coronary heart. I sincerely hope that you can also undertake a few of its implications into your each day life.
A Word From Dr. Mercola Concerning the Writer
A Midwestern Physician (AMD) is a board-certified doctor within the Midwest and a longtime reader of Mercola.com. I admire his distinctive perception on a variety of subjects and I am grateful to share them. I additionally respect his need to stay nameless as he’s nonetheless on the entrance traces treating sufferers. To search out extra of AMD’s work, make sure to try The Forgotten Aspect of Medication on Substack.
